This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Barrow, W W Articles by Brennan, P J Search for Related Content PubMed PubMed Citation Articles by Barrow, W W Articles by Brennan, P J

 Previous Article  |  Next Article 

J Bacteriol. 1980 November; 144(2): 814-822

Peptidoglycolipid nature of the superficial cell wall sheath of smooth-colony-forming mycobacteria.

ABSTRACT

The most superficial cell wall layer present in smooth-colony-forming mycobacteria was isolated from serovar 20 of the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum (MAIS) serocomplex and examined chemically and by electron microscopy. Most (70 to 80%) of the fibrillar material consisted of an array of serologically active, acetylated C-myosidic peptidoglycoplipids with the basic structure (formula, see text) but in which the location of acetyl groups and the arrangement of monosaccharides have not been defined. Apparently, all serovars within the MAIS complex are characterized by structurally related superficies in which the monoglycosyl-lipopeptide portion is invariable but the oligosaccharide attachment is peculiar to each serovar. These unique inert structures may be an important factor in shielding the pathogen within phagolysosomes from lysosomal enzymes.

This article has been cited by other articles:

• Alteri, C. J., Xicohtencatl-Cortes, J., Hess, S., Caballero-Olin, G., Giron, J. A., Friedman, R. L. (2007). Mycobacterium tuberculosis produces pili during human infection. Proc. Natl. Acad. Sci. USA 104: 5145-5150 [Abstract] [Full Text]  
• Sweet, L., Schorey, J. S. (2006). Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner. J. Leukoc. Biol. 80: 415-423 [Abstract] [Full Text]  
• Howard, S. T., Rhoades, E., Recht, J., Pang, X., Alsup, A., Kolter, R., Lyons, C. R., Byrd, T. F. (2006). Spontaneous reversion of Mycobacterium abscessus from a smooth to a rough morphotype is associated with reduced expression of glycopeptidolipid and reacquisition of an invasive phenotype. Microbiology 152: 1581-1590 [Abstract] [Full Text]  
• Mukherjee, R., Gomez, M., Jayaraman, N., Smith, I., Chatterji, D. (2005). Hyperglycosylation of glycopeptidolipid of Mycobacterium smegmatis under nutrient starvation: structural studies. Microbiology 151: 2385-2392 [Abstract] [Full Text]  
• Ojha, A. Kr., Varma, S., Chatterji, D. (2002). Synthesis of an unusual polar glycopeptidolipid in glucose-limited culture of Mycobacterium smegmatis. Microbiology 148: 3039-3048 [Abstract] [Full Text]  
• Tse, H. M., Josephy, S. I., Chan, E. D., Fouts, D., Cooper, A. M. (2002). Activation of the Mitogen-Activated Protein Kinase Signaling Pathway Is Instrumental in Determining the Ability of Mycobacterium avium to Grow in Murine Macrophages. J. Immunol. 168: 825-833 [Abstract] [Full Text]  
• Martínez, A., Torello, S., Kolter, R. (1999). Sliding Motility in Mycobacteria. J. Bacteriol. 181: 7331-7338 [Abstract] [Full Text]