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J Bacteriol. 1981 March; 145(3): 1150-1153

Threonine as a carbon source for Escherichia coli.

T T Chan and E B Newman

ABSTRACT

Threonine can be used aerobically as the sole source of carbon and energy by mutants of Escherichia coli K-12. The pathway used involves the conversion of threonine via threonine dehydrogenase to aminoketobutyric acid, which is further metabolized by aminoketobutyric acid ligase, forming acetyl coenzyme A and glycine. A strain devoid of serine transhydroxymethylase uses this pathway and excretes glycine as a waste product. Aminoketobutyric acid ligase activity was demonstrated after passage of crude extracts through Sephadex G100.

J Bacteriol. 1981 March; 145(3): 1150-1153






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