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J Bacteriol. 1981 November; 148(2): 716-719

Deoxyribonucleic acid methylation in mycobacteria.

R Srivastava, K P Gopinathan and T Ramakrishnan

ABSTRACT

Deoxyribonucleic acid modification in six strains of mycobacteria was investigated. The presence of 5-methylcytosine in the virulent strain Mycobacterium tuberculosis H37Rv and its absence in the avirulent strain M. tuberculosis H37Ra and other saprophytic, fast-growing mycobacteria appear to be the salient features. However, deoxyribonucleic acid from M. smegmatis SN2 lysogenized with the temperature phage I3 showed the presence of 5-methylcytosine. All of the strains had N6-methyladenine.

J Bacteriol. 1981 November; 148(2): 716-719






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