This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Osman, Y A Articles by Ingram, L O Search for Related Content PubMed PubMed Citation Articles by Osman, Y A Articles by Ingram, L O

Mechanism of ethanol inhibition of fermentation in Zymomonas mobilis CP4.

ABSTRACT

Accumulation of alcohol during fermentation is accompanied by a progressive decrease in the rate of sugar conversion to ethanol. In this study, we provided evidence that inhibition of fermentation by ethanol can be attributed to an indirect effect of ethanol on the enzymes of glycolysis involving the plasma membrane. Ethanol decreased the effectiveness of the plasma membrane as a semipermeable barrier, allowing leakage of essential cofactors and coenzymes. This leakage of cofactors and coenzymes, coupled with possible additional leakage of intermediary metabolites en route to ethanol formation, is sufficient to explain the inhibitory effects of ethanol on fermentation in Zymomonas mobilis.

This article has been cited by other articles:

• Zhao, Y., Hindorff, L. A., Chuang, A., Monroe-Augustus, M., Lyristis, M., Harrison, M. L., Rudolph, F. B., Bennett, G. N. (2003). Expression of a Cloned Cyclopropane Fatty Acid Synthase Gene Reduces Solvent Formation in Clostridium acetobutylicum ATCC 824. Appl. Environ. Microbiol. 69: 2831-2841 [Abstract] [Full Text]  
• Graca da Silveira, M., Vitoria San Romao, M., Loureiro-Dias, M. C., Rombouts, F. M., Abee, T. (2002). Flow Cytometric Assessment of Membrane Integrity of Ethanol-Stressed Oenococcus oeni Cells. Appl. Environ. Microbiol. 68: 6087-6093 [Abstract] [Full Text]  
• Zhou, S., Yomano, L. P., Saleh, A. Z., Davis, F. C., Aldrich, H. C., Ingram, L. O. (1999). Enhancement of Expression and Apparent Secretion of Erwinia chrysanthemi Endoglucanase (Encoded by celZ) in Escherichia coli B. Appl. Environ. Microbiol. 65: 2439-2445 [Abstract] [Full Text]