This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jones, B L Articles by Keister, D L Search for Related Content PubMed PubMed Citation Articles by Jones, B L Articles by Keister, D L

Inhibition of growth of Rhizobium japonicum by cyclic GMP.

ABSTRACT

Exogenous cyclic guanosine-3',5'-monophosphate (cGMP) inhibited the growth of Rhizobium japonicum at less than 100 microM. Other nucleotides, including cyclic AMP, cyclic IMP, and cyclic CMP, had no inhibitory effect even at higher concentrations nor was the inhibition by cGMP reversed by cyclic AMP. The inhibitory effect was independent of the carbon and nitrogen source(s) used. cGMP did not inhibit the growth of any other species of bacterium tested, including several fast-growing Rhizobium species. The kinetics of growth inhibition are multiphasic, with no apparent effect for several hours after addition, followed by a period of total inhibition. Subsequently, growth resumed at a slower rate. Resumption of growth was not due to destruction of the nucleotide. Studies of the intracellular cGMP concentration did not reveal significant changes in cells grown under aerobic or microaerobic conditions. No effect of cGMP on the derepression of respiratory nitrate reductase was observed.

This article has been cited by other articles:

• Tellez-Sosa, J., Soberon, N., Vega-Segura, A., Torres-Marquez, M. E., Cevallos, M. A. (2002). The Rhizobium etli cyaC Product: Characterization of a Novel Adenylate Cyclase Class. J. Bacteriol. 184: 3560-3568 [Abstract] [Full Text]