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J Bacteriol. 1987 December; 169(12): 5504-5509

Involvement of heat shock proteins in bacteriophage Mu development.

Department of Molecular and Cellular Biology, National Jewish Center for Immunology, and Respiratory Medicine, Denver, Colorado.

ABSTRACT

Growth of bacteriophage Mu was severely inhibited at elevated temperature in mutants defective in the heat shock genes dnaK, groEL, and groES and in the rpoH (htpR) regulatory mutant, but not in mutants defective in the heat shock genes dnaJ or grpE; growth of a mutant of Mu deficient in functions encoded in the accessory region of the Mu genome was inhibited in the latter two host mutants. Phage production in the dnaJ mutant was restored by growth in low-salt medium. The stage in Mu development primarily affected in all except the groE mutants was phage late transcription. In contrast, the groE mutants did not support growth of Mu at any temperature; neither Mu DNA replication nor transcription was inhibited in these strains, suggesting that groE is required for phage morphogenesis as observed with several other coliphages.

This article has been cited by other articles:

• Grimaud, R., Toussaint, A. (1998). Assembly of Both the Head and Tail of Bacteriophage Mu Is Blocked in Escherichia coli groEL and groES Mutants. J. Bacteriol. 180: 1148-1153 [Abstract] [Full Text]