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research-article

Replication termination for staphylococcal plasmids: plasmids pT181 and pC221 cross-react in the termination process.

Department of Plasmid Biology, Public Health Research Institute, New York, New York 10016.

ABSTRACT

We present data which indicate that (i) the origin of replication of plasmids pT181 and pC221 can also function as termination signals; (ii) termination of replication occurs when a round of replication initiated either by RepC at the pT181 origin or by RepD at the pC221 origin reaches either of these origins, proving that the two plasmids cross-react for termination of replication; and (iii) the replication initiated at the origin of another staphylococcal plasmid, pE194, does not terminate at the origin of pT181 or pC221, indicating the existence of a specific relationship between the initiation and termination of a replication event.