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J Bacteriol. 1992 June; 174(11): 3645-3650

research-article

The Escherichia coli K-12 cyn operon is positively regulated by a member of the lysR family.

Y C Sung and J A Fuchs

Department of Biochemistry, University of Minnesota, St. Paul 55108.

ABSTRACT

A regulatory gene, cynR, was found to be located next to the cyn operon but transcribed in the opposite direction. cynR encodes a positive regulatory protein that controls the cyn operon as well as its own synthesis. Positive regulation of the cyn operon requires cyanate and the cynR protein, but the negative autoregulation of the cynR gene appears to be independent of cyanate. The predicted amino acid sequence of the cynR protein derived from the DNA sequence was found to have significant homology to the predicted amino acid sequence of the lysR family of regulatory proteins.


J Bacteriol. 1992 June; 174(11): 3645-3650




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