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J Bacteriol. 1992 June; 174(12): 4179-4182

research-article

Doublet translocation at GGA is mediated directly by mutant tRNA(2Gly).

Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston 77030.

ABSTRACT

Members of the sufS class of -1 frameshift suppressors have alterations of the GGA/G-decoding tRNA(2Gly). Suppressor-promoted frameshifting at GGA was shown in this study to be directly mediated by the mutant tRNA(2Gly). We disproved the possibility that, in the presence of the compromised mutant tRNA(2Gly), either wild-type tRNA(1Gly), wild-type tRNA(3Gly), a GGA-reading mutant form of tRNA(3Gly), or any other agent suppresses the frameshift mutation trpE91.

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