This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Godon, J J Articles by Ehrlich, S D Search for Related Content PubMed PubMed Citation Articles by Godon, J J Articles by Ehrlich, S D

research-article

Branched-chain amino acid biosynthesis genes in Lactococcus lactis subsp. lactis.

Laboratoire de Génétique Microbienne, Institut National de la Recherche Agronomique, Jouy-en-Josas, France.

ABSTRACT

The genes for biosynthesis of the branched-chain amino acids leucine, isoleucine, and valine in Lactococcus lactis subsp. lactis NCDO2118 were characterized by cloning, complementation in Escherichia coli and Bacillus subtilis, and nucleotide sequence analysis. Nine structural genes are clustered on a 12-kb DNA fragment in the order leuABCD ilvDBNCA. Upstream of these genes, the nucleotide sequence suggests the existence of regulation by transcriptional attenuation. Between the leuD and ilvD genes is an unexpected gene, encoding a protein which belongs to the ATP-binding cassette protein superfamily.

This article has been cited by other articles:

• Garcia-Quintans, N., Repizo, G., Martin, M., Magni, C., Lopez, P. (2008). Activation of the Diacetyl/Acetoin Pathway in Lactococcus lactis subsp. lactis bv. diacetylactis CRL264 by Acidic Growth. Appl. Environ. Microbiol. 74: 1988-1996 [Abstract] [Full Text]  
• den Hengst, C. D., van Hijum, S. A. F. T., Geurts, J. M. W., Nauta, A., Kok, J., Kuipers, O. P. (2005). The Lactococcus lactis CodY Regulon: IDENTIFICATION OF A CONSERVED cis-REGULATORY ELEMENT. J. Biol. Chem. 280: 34332-34342 [Abstract] [Full Text]  
• van der Kaaij, H., Desiere, F., Mollet, B., Germond, J.-E. (2004). L-Alanine Auxotrophy of Lactobacillus johnsonii as Demonstrated by Physiological, Genomic, and Gene Complementation Approaches. Appl. Environ. Microbiol. 70: 1869-1873 [Abstract] [Full Text]  
• Chambellon, E., Yvon, M. (2003). CodY-Regulated Aminotransferases AraT and BcaT Play a Major Role in the Growth of Lactococcus lactis in Milk by Regulating the Intracellular Pool of Amino Acids. Appl. Environ. Microbiol. 69: 3061-3068 [Abstract] [Full Text]  
• Kohlhaw, G. B. (2003). Leucine Biosynthesis in Fungi: Entering Metabolism through the Back Door. Microbiol. Mol. Biol. Rev. 67: 1-15 [Abstract] [Full Text]  
• Henrich, B., Klein, J. R., Weber, B., Delorme, C., Renault, P., Wegmann, U. (2002). Food-Grade Delivery System for Controlled Gene Expression in Lactococcus lactis. Appl. Environ. Microbiol. 68: 5429-5436 [Abstract] [Full Text]  
• Chia, J.-S., Lee, Y.-Y., Huang, P.-T., Chen, J.-Y. (2001). Identification of Stress-Responsive Genes in Streptococcus mutans by Differential Display Reverse Transcription-PCR. Infect. Immun. 69: 2493-2501 [Abstract] [Full Text]  
• Garault, P., Letort, C., Juillard, V., Monnet, V. (2000). Branched-Chain Amino Acid Biosynthesis Is Essential for Optimal Growth of Streptococcus thermophilus in Milk. Appl. Environ. Microbiol. 66: 5128-5133 [Abstract] [Full Text]  
• Gosalbes, M. J., Esteban, C. D., Galán, J. L., Pérez-Martínez, G. (2000). Integrative Food-Grade Expression System Based on the Lactose Regulon of Lactobacillus casei. Appl. Environ. Microbiol. 66: 4822-4828 [Abstract] [Full Text]  
• Goupil-Feuillerat, N., Corthier, G., Godon, J.-J., Ehrlich, S. D., Renault, P. (2000). Transcriptional and Translational Regulation of alpha -Acetolactate Decarboxylase of Lactococcus lactis subsp. lactis. J. Bacteriol. 182: 5399-5408 [Abstract] [Full Text]  
• Yvon, M., Chambellon, E., Bolotin, A., Roudot-Algaron, F. (2000). Characterization and Role of the Branched-Chain Aminotransferase (BcaT) Isolated from Lactococcus lactis subsp. cremoris NCDO 763. Appl. Environ. Microbiol. 66: 571-577 [Abstract] [Full Text]  
• Craster, H. L., Potter, C. A., Baumberg, S. (1999). End-product control of expression of branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2): paradoxical relationships between DNA sequence and regulatory phenotype. Microbiology 145: 2375-2384 [Abstract] [Full Text]  
• Curic, M., Stuer-Lauridsen, B., Renault, P., Nilsson, D. (1999). A General Method for Selection of alpha -Acetolactate Decarboxylase-Deficient Lactococcus lactis Mutants To Improve Diacetyl Formation. Appl. Environ. Microbiol. 65: 1202-1206 [Abstract] [Full Text]  
• Martinussen, J., Hammer, K. (1998). The carB Gene Encoding the Large Subunit of Carbamoylphosphate Synthetase from Lactococcus lactis Is Transcribed Monocistronically. J. Bacteriol. 180: 4380-4386 [Abstract] [Full Text]