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research-article

Homology of a plasmid from the spirochete Treponema denticola with the single-stranded DNA plasmids.

Unité Bactériologie Moléculaire et Médicale, Institut Pasteur, Paris, France.

ABSTRACT

The 2,647-bp nucleotide sequence of cryptic plasmid pTD1, isolated from the oral spirochete Treponema denticola, was determined. The sequence revealed two open reading frames, A and B, which encode polypeptides of 335 and 235 amino acids, respectively. Open reading frame A shows sequence similarity to genes that encode replication proteins from a group of plasmids common in gram-positive bacteria, which replicate via a single-stranded intermediate.