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J Bacteriol. 1993 June; 175(12): 3913-3915

research-article

Leptospira genomes are modified at 5'-GTAC.

D Ralph, Q Que, J L Van Etten and M McClelland

California Institute of Biological Research, La Jolla 92037.

ABSTRACT

Genomic DNAs of 14 strains from seven species of the spirochete Leptospira were resistant to cleavage by the restriction endonuclease RsaI (5'-GTAC). A modified base comigrating with m4C was detected by chromatography. Genomic DNAs from other spirochetes, Borrelia group VS461, and Serpulina strains were not resistant to RsaI digestion. Modification at 5'-GTAm4C may occur in most or all strains of all species of Leptospira but not in all genera of spirochetes. Genus-wide DNA modification has rarely been observed in bacteria.

J Bacteriol. 1993 June; 175(12): 3913-3915






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