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J Bacteriol. 1993 November; 175(22): 7492-7494

research-article

Negative autoregulation by the Escherichia coli SoxS protein: a dampening mechanism for the soxRS redox stress response.

Department of Molecular and Cellular Toxicology, Harvard School of Public Health, Boston, Massachusetts 02115.

ABSTRACT

The soxRS redox stress regulon of Escherichia coli is triggered in two stages, with the activated SoxR protein stimulating the soxS gene, whose product then triggers transcription of approximately 10 promoters. Genetic and biochemical experiments presented here show that SoxS protein also limits soxS transcription in vivo and binds the soxS promoter in vitro.

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