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J Bacteriol. 1993 December; 175(23): 7705-7706

research-article

Glutamine synthesis is a regulatory signal controlling glucose catabolism in Saccharomyces cerevisiae.

B Flores-Samaniego, H Olivera and A González

Departamento de Microbiología, Universidad Nacional Autónoma de México, D.F., Mexico.

ABSTRACT

The effect of glutamine biosynthesis and degradation on glucose catabolism in Saccharomyces cerevisiae was studied. A wild-type strain and mutants altered in glutamine biosynthesis and degradation were analyzed. Cells having low levels of glutamine synthetase activity showed high ATP/ADP ratios and a diminished rate of glucose metabolism. It is proposed that glutamine biosynthesis plays a role in the regulation of glucose catabolism.

J Bacteriol. 1993 December; 175(23): 7705-7706






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