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research-article

The unstable melC operon of Streptomyces antibioticus is codeleted with a Tn4811-homologous locus.

Institute of Genetics, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.

ABSTRACT

The melC operon of Streptomyces antibioticus is unstable, undergoing frequent spontaneous deletions. All the delta melC mutants analyzed also lost 2-kb V1 DNA, which contained two open reading frames (ORFs) homologous to ORF4 (a putative oxidoreductase gene) and ORF5 (a putative AraC-type regulatory gene) of Tn4811. The two ORFs may constitute an accessory unit of a different transposon.

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