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J Bacteriol. 1994 July; 176(14): 4448-4454

research-article

Cloning and analysis of a locus (mcr) involved in mitomycin C resistance in Streptomyces lavendulae.

Department of Microbiology, University of Minnesota, St. Paul 55108.

ABSTRACT

Two genes (mcrA and mcrB) from Streptomyces lavendulae that together confer resistance to mitomycin C were identified. This DNA appears to comprise a polycistronic operon with a drug-inducible leaderless mRNA. The deduced amino acid sequence of mcrA shows similarity to sequences of a special class of bacterial, plant, and animal oxygen oxidoreductases.

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