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J Bacteriol. 1994 October; 176(19): 6143-6145

research-article

The min locus, which confers topological specificity to cell division, is not involved in its coupling with nucleoid separation.

Laboratoire de Microbiologie et de Génétique Moléculaire du Centre National de la Recherche Scientifique, Toulouse, France.

ABSTRACT

In Escherichia coli, nucleoid separation and cell constriction remain tightly linked when division is retarded by altering the level of synthesis of the protein FtsZ. In this study, we have examined the role of the min locus, which is responsible for the inactivation of polar division sites, in the partition-septation coupling mechanism. We conclude that the coupling persists in a delta min strain and that its timing relative to replication remains dependent on the level of FtsZ synthesis. We suggest that the retarded nucleoid segregation observed in min mutants is the result of this coupling in cells with a perturbed pattern of nonpolar divisions.

This article has been cited by other articles:

• Barák, I., Prepiak, P., Schmeisser, F. (1998). MinCD Proteins Control the Septation Process during Sporulation of Bacillus subtilis. J. Bacteriol. 180: 5327-5333 [Abstract] [Full Text]  
• Berlyn, M. K. B. (1998). Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map. Microbiol. Mol. Biol. Rev. 62: 814-984 [Abstract] [Full Text]