This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fowler, R G Articles by Isbell, R J Search for Related Content PubMed PubMed Citation Articles by Fowler, R G Articles by Isbell, R J

 Previous Article  |  Next Article 

J Bacteriol. 1994 December; 176(24): 7727-7729

research-article

Activity of the Escherichia coli mutT mutator allele in an anaerobic environment.

Department of Biological Sciences, San Jose State University, California 95192.

ABSTRACT

Mutation frequencies for an Escherichia coli mutT strain were measured in both aerobic and anaerobic environments. When cells were grown in a rich medium (L broth), mutation frequencies were similar in both aerobic and anaerobic conditions. In contrast, when grown in a minimal medium, mutT anaerobic mutation frequencies were reduced dramatically compared with aerobic values, which were similar to L broth frequencies. L broth mutT cultures treated with a commercial enzyme complex that reduces free oxygen in the medium also showed strongly reduced anaerobic mutation frequencies. These results indicate that the biological role of the MutT protein is to prevent oxidative damage from becoming mutagenic.

This article has been cited by other articles:

• Mathews, C. K. (2006). DNA precursor metabolism and genomic stability. FASEB J. 20: 1300-1314 [Abstract] [Full Text]  
• Tassotto, M. L., Mathews, C. K. (2002). Assessing the Metabolic Function of the MutT 8-Oxodeoxyguanosine Triphosphatase in Escherichia coli by Nucleotide Pool Analysis. J. Biol. Chem. 277: 15807-15812 [Abstract] [Full Text]  
• Berlyn, M. K. B. (1998). Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map. Microbiol. Mol. Biol. Rev. 62: 814-984 [Abstract] [Full Text]  
• Sheikh, S., O'Handley, S. F., Dunn, C. A., Bessman, M. J. (1998). Identification and Characterization of the Nudix Hydrolase from the Archaeon, Methanococcus jannaschii, as a Highly Specific ADP-ribose Pyrophosphatase. J. Biol. Chem. 273: 20924-20928 [Abstract] [Full Text]  
• Taddei, F., Hayakawa, H., Bouton, M., Cirinesi, A., Matic, I., Sekiguchi, M., Radman, M. (1997). Counteraction by MutT Protein of Transcriptional Errors Caused by Oxidative Damage. Science 278: 128-130 [Abstract] [Full Text]