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J. Bacteriol., Sep 1995, 5355-5357, Vol 177, No. 18
Copyright © 1995, American Society for Microbiology

Genetic analysis suggests functional interactions between the N- and C- terminal domains of the TetA(C) efflux pump encoded by pBR322

P McNicholas, M McGlynn, GG Guay and DM Rothstein
Department of Microbial Genetics and Biochemistry, Lederle Laboratories, Pearl River, New York 10965, USA.

Genetic analysis of the tetA(C) gene of pBR322 indicates the importance of two-cytoplasmic loops in the TetA(C) protein (P. McNicholas, I. Chopra, and D. M. Rothstein, J. Bacteriol. 174:7926-7933, 1992). In this study, we characterized second-site suppressor mutations that suggest a functional interaction between these two cytoplasmic regions of the protein.

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