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J. Bacteriol., Sep 1995, 5381-5382, Vol 177, No. 18
Copyright © 1995, American Society for Microbiology

Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP

SC King, SR Fleming and C Brechtel
Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston 77555-0641, USA.

Although considered selective for its natural substrate, 4- aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3- pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4- aminobutyrate via counterflow.

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