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J. Bacteriol., 10 1995, 5696-5700, Vol 177, No. 19
Copyright © 1995, American Society for Microbiology

Mutations in GltC that increase Bacillus subtilis gltA expression

BR Belitsky and AL Sonenshein
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

Mutants with altered forms of GltC, a positive LysR-type regulator of Bacillus subtilis glutamate synthase gene expression, were isolated. The mutant GltC proteins stimulated expression from the wild-type gltA promoter region 1.5- to 2.0-fold and from mutant promoter regions up to 80-fold. Moreover, expression of gltA became much less dependent on a nitrogen source-associated signal.

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