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J. Bacteriol., 10 1995, 5704-5706, Vol 177, No. 19
Copyright © 1995, American Society for Microbiology

Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system

DG Cvitkovitch, DA Boyd and IR Hamilton
Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada.

In this report, we provide evidence that the transport of sugars in Streptococcus mutans via the multiple sugar metabolism system is regulated by the phosphoenolpyruvate phosphotransferase system. A ptsI- defective mutant (DC10), when grown on the multiple sugar metabolism system substrate raffinose, exhibited reduced growth, transport, and glycolytic activity with raffinose relative to the parent strain BM71. Inhibition of [3H]raffinose uptake was also observed in both BM71 and DC10 with increasing concentrations of glucose and the glucose analogs alpha-methyl glucoside and 2-deoxyglucose.

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