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J. Bacteriol., 10 1995, 5997-6000, Vol 177, No. 20
Copyright © 1995, American Society for Microbiology

Transcriptional analysis of the Yersinia pestis pH 6 antigen gene

SB Price, MD Freeman and KS Yeh
Department of Pathobiology, College of Veterinary Medicine, Auburn University, Alabama 36849, USA.

The pH 6 antigen of Yersinia pestis is a virulence protein whose gene, psaA, is positively regulated at the transcriptional level by low pH, mammalian temperature, and an upstream locus, psaE. Low pH appears to be required for initial psaA transcription, although increased temperature is necessary for full expression of the gene. In addition, psaA is monocistronic and its transcript has a relatively long 5' nontranslated region.

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