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J. Bacteriol., Feb 1995, 1082-1085, Vol 177, No. 4
Copyright © 1995, American Society for Microbiology

Sporulation protein SpoIVFB from Bacillus subtilis enhances processing of the sigma factor precursor Pro-sigma K in the absence of other sporulation gene products

S Lu, S Cutting and L Kroos
Department of Biochemistry, Michigan State University, East Lansing 48824.

Processing of inactive pro-sigma K to active sigma K in the mother cell compartment of sporulating Bacillus subtilis is governed by a signal transduction pathway emanating from the forespore and involving SpoIVFB in the mother cell. Coexpression of spoIVFB and sigK (encoding pro- sigma K) genes in growing B. subtilis or Escherichia coli enhanced pro- sigma K processing in the absence of other sporulation-specific gene products. The simplest explanation of these results is that SpoIVFB is a protease that processes pro-sigma K.

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