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J. Bacteriol., Apr 1995, 2194-2196, Vol 177, No. 8
Copyright © 1995, American Society for Microbiology

Cross-species complementation of the indispensable Escherichia coli era gene highlights amino acid regions essential for activity

RC Pillutla, JD Sharer, PS Gulati, E Wu, Y Yamashita, CG Lerner, M Inouye and PE March
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway 08854, USA.

Era is an essential GTP binding protein in Escherichia coli. Two homologs of this protein, Sgp from Streptococcus mutans and Era from Coxiella burnetii, can substitute for the essential function of Era in E. coli. Site-specific and randomly generated Era mutants which may indicate regions of the protein that are of functional importance are described.


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