J. Bacteriol., Jan 1996, 280-283, Vol 178, No. 1
Copyright © 1996, American Society for Microbiology

Frur mediates catabolite activation of pyruvate kinase (pykF) gene expression in Escherichia coli

SA Bledig, TM Ramseier and MH Saier Jr
Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.

Expression of a pykF-lacZ fusion was studied as a function of the carbon source in wild-type strains and strains lacking or overproducing the FruR protein of Escherichia coli. FruR controls the response to the carbon source by repressing pykF expression more strongly under gluconeogenic than under glycolytic conditions, a phenomenon we term catabolite activation.

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