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J. Bacteriol., Jun 1996, 3608-3613, Vol 178, No. 12
Copyright © 1996, American Society for Microbiology

Involvement of the DnaK-DnaJ-GrpE chaperone team in protein secretion in Escherichia coli

J Wild, P Rossmeissl, WA Walter and CA Gross
Department of Bacteriology, University of Wisconsin-Madison, 53706, USA.

We used depletion studies designed to further investigate the role of the DnaK, DnaJ, and GrpE heat shock proteins in the SecB-dependent and SecB-independent secretion pathways. Our previous finding that SecB- deficient strains containing the grpE280 mutation were still secretion proficient raised the possibility that GrpE was not involved in this secretory pathway. Using depletion studies, we now demonstrate a requirement for GrpE in this pathway. In addition, depletion studies demonstrate that while DnaK, DnaJ, and GrpE are involved in the secretion of the SecB-independent proteins (alkaline phosphatase, ribose-binding protein, and beta-lactamase), they are not the primary chaperones in this process.


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