Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

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J. Bacteriol., 07 1996, 3885-3892, Vol 178, No. 13
Copyright © 1996, American Society for Microbiology

Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

MM Slupska, C Baikalov, WM Luther, JH Chiang, YF Wei and JH Miller
Department of Microbiology and Molecular Genetics, University of California, Los Angeles, California 90024, USA.

We have cloned the human mutY gene (hMYH) from both genomic and cDNA libraries. The human gene contains 15 introns and is 7.1 kb long. The 16 exons encode a protein of 535 amino acids that displays 41% identity to the Escherichia coli protein, which provides an important function in the repair of oxidative damage to DNA and helps to prevent mutations from oxidative lesions. The human mutY gene maps on the short arm of chromosome 1, between p32.1 and p34.3.

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Le Page, F., Klungland, A., Barnes, D. E., Sarasin, A., Boiteux, S. (2000). Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences. Proc. Natl. Acad. Sci. USA 10.1073/pnas.140137297v1 [Abstract] [Full Text]
Wang, G., Hazra, T. K., Mitra, S., Lee, H.-M., Englander, E. W. (2000). Mitochondrial DNA damage and a hypoxic response are induced by CoCl2 in rat neuronal PC12 cells. Nucleic Acids Res 28: 2135-2140 [Abstract] [Full Text]
Miyako, K., Takamatsu, C., Umeda, S., Tajiri, T., Furuichi, M., Nakabeppu, Y., Sekiguchi, M., Hamasaki, N., Takeshige, K., Kang, D. (2000). Accumulation of Adenine DNA Glycosylase-sensitive Sites in Human Mitochondrial DNA. J. Biol. Chem. 275: 12326-12330 [Abstract] [Full Text]
Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T., Nakabeppu, Y. (2000). Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria. Nucleic Acids Res 28: 1355-1364 [Abstract] [Full Text]
Asagoshi, K., Yamada, T., Terato, H., Ohyama, Y., Monden, Y., Arai, T., Nishimura, S., Aburatani, H., Lindahl, T., Ide, H. (2000). Distinct Repair Activities of Human 7,8-Dihydro-8-oxoguanine DNA Glycosylase and Formamidopyrimidine DNA Glycosylase for Formamidopyrimidine and 7,8-Dihydro-8-oxoguanine. J. Biol. Chem. 275: 4956-4964 [Abstract] [Full Text]
Lindahl, T., Wood, R. D. (1999). Quality Control by DNA Repair. Science 286: 1897-1905 [Abstract] [Full Text]
Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., Barnes, D. E. (1999). Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc. Natl. Acad. Sci. USA 96: 13300-13305 [Abstract] [Full Text]
Wright, P. M., Yu, J., Cillo, J., Lu, A-L. (1999). The Active Site of the Escherichia coli MutY DNA Adenine Glycosylase. J. Biol. Chem. 274: 29011-29018 [Abstract] [Full Text]
Slupska, M. M., Luther, W. M., Chiang, J.-H., Yang, H., Miller, J. H. (1999). Functional Expression of hMYH, a Human Homolog of the Escherichia coli MutY Protein. J. Bacteriol. 181: 6210-6213 [Abstract] [Full Text]
Nishioka, K., Ohtsubo, T., Oda, H., Fujiwara, T., Kang, D., Sugimachi, K., Nakabeppu, Y. (1999). Expression and Differential Intracellular Localization of Two Major Forms of Human 8-Oxoguanine DNA Glycosylase Encoded by Alternatively Spliced OGG1 mRNAs. Mol. Biol. Cell 10: 1637-1652 [Abstract] [Full Text]
Lu, A-L., Fawcett, W. P. (1998). Characterization of the Recombinant MutY Homolog, an Adenine DNA Glycosylase, from Yeast Schizosaccharomyces pombe. J. Biol. Chem. 273: 25098-25105 [Abstract] [Full Text]
Saparbaev, M., Laval, J. (1998). 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase. Proc. Natl. Acad. Sci. USA 95: 8508-8513 [Abstract] [Full Text]
BECKMAN, K. B., AMES, B. N. (1998). The Free Radical Theory of Aging Matures. Physiol. Rev. 78: 547-581 [Abstract] [Full Text]
Wilson, D. M. III, Thompson, L. H. (1997). Life without DNA�repair. Proc. Natl. Acad. Sci. USA 94: 12754-12757 [Full Text]
Kuo, F. C., Sklar, J. (1997). Augmented Expression of a Human Gene for 8-oxoguanine DNA Glycosylase (MutM) in B Lymphocytes of the Dark Zone in Lymph Node Germinal Centers. J. Exp. Med. 186: 1547-1556 [Abstract] [Full Text]
Croteau, D. L., Bohr, V. A. (1997). Repair of Oxidative Damage to Nuclear and Mitochondrial DNA in Mammalian Cells. J. Biol. Chem. 272: 25409-25412 [Full Text]
Beckman, K. B., Ames, B. N. (1997). Oxidative Decay of DNA. J. Biol. Chem. 272: 19633-19636 [Full Text]
Radicella, J. P., Dherin, C., Desmaze, C., Fox, M. S., Boiteux, S. (1997). Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces�cerevisiae. Proc. Natl. Acad. Sci. USA 94: 8010-8015 [Abstract] [Full Text]
Zharkov, D. O., Rosenquist, T. A., Gerchman, S. E., Grollman, A. P. (2000). Substrate Specificity and Reaction Mechanism of Murine 8-Oxoguanine-DNA Glycosylase. J. Biol. Chem. 275: 28607-28617 [Abstract] [Full Text]
Parker, A., Gu, Y., Mahoney, W., Lee, S.-H., Singh, K. K., Lu, A-L. (2001). Human Homolog of the MutY Repair Protein (hMYH) Physically Interacts with Proteins Involved in Long Patch DNA Base Excision Repair. J. Biol. Chem. 276: 5547-5555 [Abstract] [Full Text]
Le Page, F., Klungland, A., Barnes, D. E., Sarasin, A., Boiteux, S. (2000). Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences. Proc. Natl. Acad. Sci. USA 97: 8397-8402 [Abstract] [Full Text]

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