J. Bacteriol., Aug 1996, 4742-4746, Vol 178, No. 15
Copyright © 1996, American Society for Microbiology

Glutathione amide and its perthiol in anaerobic sulfur bacteria

RG Bartsch, GL Newton, C Sherrill and RC Fahey
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92093, USA.

Chromatium species produced the novel biological thiol glutathione amide, gamma-L-glutamyl-L-cysteinylglycine amide (GASH), when grown photoheterotrophically. GASH was largely converted to the corresponding perthiol during photoautotrophic growth on sulfide, suggesting that GASH may have a function in anaerobic sulfide metabolism. This unprecedented form of glutathione metabolism was probably present in anaerobic ancestors of modern cyanobacteria and purple bacteria.

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