J. Bacteriol., 11 1996, 6366-6368, Vol 178, No. 21
Copyright © 1996, American Society for Microbiology
ML Gwinn, D Yi, HO Smith and JF Tomb
Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA. mgwinn@welchlink.welch.jhu.edu
Haemophilus influenzae Rd becomes competent for transformation by nutritional downshift or transient anaerobic growth through a process that requires cyclic AMP receptor protein and adenylate cyclase. Insertion mutations in crr or ptsI of the phosphoenolpyruvate:carbohydrate phosphotransferase system lowered transformation frequencies, and the effect was reversed by the addition of cyclic AMP. However, insertions into H. influenzae homologs of two- component signal transduction genes had no effect on competence.
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