This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Givskov, M.
Right arrow Articles by Kjelleberg, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Givskov, M.
Right arrow Articles by Kjelleberg, S.

 Previous Article  |  Next Article 

J. Bacteriol., 11 1996, 6618-6622, Vol 178, No. 22
Copyright © 1996, American Society for Microbiology

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

M Givskov, R de Nys, M Manefield, L Gram, R Maximilien, L Eberl, S Molin, PD Steinberg and S Kjelleberg
Department of Microbiology, The Technical University of Denmark, Lyngby.

Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface- associated bacteria may be mediated by interference with bacterial regulatory systems.


This article has been cited by other articles:

  • Kuehl, R., Al-Bataineh, S., Gordon, O., Luginbuehl, R., Otto, M., Textor, M., Landmann, R. (2009). Furanone at Subinhibitory Concentrations Enhances Staphylococcal Biofilm Formation by luxS Repression. Antimicrob. Agents Chemother. 53: 4159-4166 [Abstract] [Full Text]  
  • Karatan, E., Watnick, P. (2009). Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms. Microbiol. Mol. Biol. Rev. 73: 310-347 [Abstract] [Full Text]  
  • Ferluga, S., Venturi, V. (2009). OryR Is a LuxR-Family Protein Involved in Interkingdom Signaling between Pathogenic Xanthomonas oryzae pv. oryzae and Rice. J. Bacteriol. 191: 890-897 [Abstract] [Full Text]  
  • Teasdale, M. E., Liu, J., Wallace, J., Akhlaghi, F., Rowley, D. C. (2009). Secondary Metabolites Produced by the Marine Bacterium Halobacillus salinus That Inhibit Quorum Sensing-Controlled Phenotypes in Gram-Negative Bacteria. Appl. Environ. Microbiol. 75: 567-572 [Abstract] [Full Text]  
  • Janssens, J. C. A., Steenackers, H., Robijns, S., Gellens, E., Levin, J., Zhao, H., Hermans, K., De Coster, D., Verhoeven, T. L., Marchal, K., Vanderleyden, J., De Vos, D. E., De Keersmaecker, S. C. J. (2008). Brominated Furanones Inhibit Biofilm Formation by Salmonella enterica Serovar Typhimurium. Appl. Environ. Microbiol. 74: 6639-6648 [Abstract] [Full Text]  
  • Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, T., Tolker-Nielsen, T., Hoiby, N., Givskov, M. (2008). Effects of Antibiotics on Quorum Sensing in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 52: 3648-3663 [Abstract] [Full Text]  
  • Popat, R., Crusz, S. A., Diggle, S. P. (2008). The social behaviours of bacterial pathogens. Br Med Bull 87: 63-75 [Abstract] [Full Text]  
  • Uroz, S., Oger, P. M., Chapelle, E., Adeline, M.-T., Faure, D., Dessaux, Y. (2008). A Rhodococcus qsdA-Encoded Enzyme Defines a Novel Class of Large-Spectrum Quorum-Quenching Lactonases. Appl. Environ. Microbiol. 74: 1357-1366 [Abstract] [Full Text]  
  • Morohoshi, T., Shiono, T., Takidouchi, K., Kato, M., Kato, N., Kato, J., Ikeda, T. (2007). Inhibition of Quorum Sensing in Serratia marcescens AS-1 by Synthetic Analogs of N-Acylhomoserine Lactone. Appl. Environ. Microbiol. 73: 6339-6344 [Abstract] [Full Text]  
  • Junker, L. M., Clardy, J. (2007). High-Throughput Screens for Small-Molecule Inhibitors of Pseudomonas aeruginosa Biofilm Development. Antimicrob. Agents Chemother. 51: 3582-3590 [Abstract] [Full Text]  
  • Sanchez-Contreras, M., Bauer, W. D, Gao, M., Robinson, J. B, Allan Downie, J (2007). Quorum-sensing regulation in rhizobia and its role in symbiotic interactions with legumes. Phil Trans R Soc B 362: 1149-1163 [Abstract] [Full Text]  
  • Dong, Y.-H., Wang, L.-H., Zhang, L.-H. (2007). Quorum-quenching microbial infections: mechanisms and implications. Phil Trans R Soc B 362: 1201-1211 [Abstract] [Full Text]  
  • Bjarnsholt, T., Givskov, M. (2007). Quorum-sensing blockade as a strategy for enhancing host defences against bacterial pathogens. Phil Trans R Soc B 362: 1213-1222 [Abstract] [Full Text]  
  • Diggle, S. P, Gardner, A., West, S. A, Griffin, A. S (2007). Evolutionary theory of bacterial quorum sensing: when is a signal not a signal?. Phil Trans R Soc B 362: 1241-1249 [Abstract] [Full Text]  
  • Taylor, M. W., Radax, R., Steger, D., Wagner, M. (2007). Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential. Microbiol. Mol. Biol. Rev. 71: 295-347 [Abstract] [Full Text]  
  • Ishida, T., Ikeda, T., Takiguchi, N., Kuroda, A., Ohtake, H., Kato, J. (2007). Inhibition of Quorum Sensing in Pseudomonas aeruginosa by N-Acyl Cyclopentylamides. Appl. Environ. Microbiol. 73: 3183-3188 [Abstract] [Full Text]  
  • Bottomley, M. J., Muraglia, E., Bazzo, R., Carfi, A. (2007). Molecular Insights into Quorum Sensing in the Human Pathogen Pseudomonas aeruginosa from the Structure of the Virulence Regulator LasR Bound to Its Autoinducer. J. Biol. Chem. 282: 13592-13600 [Abstract] [Full Text]  
  • Labbate, M., Zhu, H., Thung, L., Bandara, R., Larsen, M. R., Willcox, M. D. P., Givskov, M., Rice, S. A., Kjelleberg, S. (2007). Quorum-Sensing Regulation of Adhesion in Serratia marcescens MG1 Is Surface Dependent. J. Bacteriol. 189: 2702-2711 [Abstract] [Full Text]  
  • Gonzalez, J. E., Keshavan, N. D. (2006). Messing with Bacterial Quorum Sensing. Microbiol. Mol. Biol. Rev. 70: 859-875 [Abstract] [Full Text]  
  • Karamanoli, K., Lindow, S. E. (2006). Disruption of N-Acyl Homoserine Lactone-Mediated Cell Signaling and Iron Acquisition in Epiphytic Bacteria by Leaf Surface Compounds. Appl. Environ. Microbiol. 72: 7678-7686 [Abstract] [Full Text]  
  • Wang, W.-B., Lai, H.-C., Hsueh, P.-R., Chiou, R. Y.-Y., Lin, S.-B., Liaw, S.-J. (2006). Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol.. J Med Microbiol 55: 1313-1321 [Abstract] [Full Text]  
  • Defoirdt, T., Crab, R., Wood, T. K., Sorgeloos, P., Verstraete, W., Bossier, P. (2006). Quorum Sensing-Disrupting Brominated Furanones Protect the Gnotobiotic Brine Shrimp Artemia franciscana from Pathogenic Vibrio harveyi, Vibrio campbellii, and Vibrio parahaemolyticus Isolates. Appl. Environ. Microbiol. 72: 6419-6423 [Abstract] [Full Text]  
  • Burmolle, M., Webb, J. S., Rao, D., Hansen, L. H., Sorensen, S. J., Kjelleberg, S. (2006). Enhanced biofilm formation and increased resistance to antimicrobial agents and bacterial invasion are caused by synergistic interactions in multispecies biofilms.. Appl. Environ. Microbiol. 72: 3916-3923 [Abstract] [Full Text]  
  • Rasmussen, T. B., Givskov, M. (2006). Quorum sensing inhibitors: a bargain of effects.. Microbiology 152: 895-904 [Abstract] [Full Text]  
  • Keshavan, N. D., Chowdhary, P. K., Haines, D. C., Gonzalez, J. E. (2005). L-Canavanine Made by Medicago sativa Interferes with Quorum Sensing in Sinorhizobium meliloti. J. Bacteriol. 187: 8427-8436 [Abstract] [Full Text]  
  • McLean, R. J. C., Barnes, M. B., Windham, M. K., Merchant, M., Forstner, M. R. J., Fuqua, C. (2005). Cell-Cell Influences on Bacterial Community Development in Aquatic Biofilms. Appl. Environ. Microbiol. 71: 8987-8990 [Abstract] [Full Text]  
  • Koch, B., Liljefors, T., Persson, T., Nielsen, J., Kjelleberg, S., Givskov, M. (2005). The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors. Microbiology 151: 3589-3602 [Abstract] [Full Text]  
  • Williamson, L. L., Borlee, B. R., Schloss, P. D., Guan, C., Allen, H. K., Handelsman, J. (2005). Intracellular Screen To Identify Metagenomic Clones That Induce or Inhibit a Quorum-Sensing Biosensor. Appl. Environ. Microbiol. 71: 6335-6344 [Abstract] [Full Text]  
  • Uroz, S., Chhabra, S. R., Camara, M., Williams, P., Oger, P., Dessaux, Y. (2005). N-Acylhomoserine lactone quorum-sensing molecules are modified and degraded by Rhodococcus erythropolis W2 by both amidolytic and novel oxidoreductase activities. Microbiology 151: 3313-3322 [Abstract] [Full Text]  
  • Visick, K. L., Fuqua, C. (2005). Decoding Microbial Chatter: Cell-Cell Communication in Bacteria. J. Bacteriol. 187: 5507-5519 [Full Text]  
  • Rasmussen, T. B., Skindersoe, M. E., Bjarnsholt, T., Phipps, R. K., Christensen, K. B., Jensen, P. O., Andersen, J. B., Koch, B., Larsen, T. O., Hentzer, M., Eberl, L., Hoiby, N., Givskov, M. (2005). Identity and effects of quorum-sensing inhibitors produced by Penicillium species. Microbiology 151: 1325-1340 [Abstract] [Full Text]  
  • Rasmussen, T. B., Bjarnsholt, T., Skindersoe, M. E., Hentzer, M., Kristoffersen, P., Kote, M., Nielsen, J., Eberl, L., Givskov, M. (2005). Screening for Quorum-Sensing Inhibitors (QSI) by Use of a Novel Genetic System, the QSI Selector. J. Bacteriol. 187: 1799-1814 [Abstract] [Full Text]  
  • Espinosa-Urgel, M., Ramos, J.-L. (2004). Cell Density-Dependent Gene Contributes to Efficient Seed Colonization by Pseudomonas putida KT2440. Appl. Environ. Microbiol. 70: 5190-5198 [Abstract] [Full Text]  
  • Parsek, M. R., Fuqua, C. (2004). Biofilms 2003: Emerging Themes and Challenges in Studies of Surface-Associated Microbial Life. J. Bacteriol. 186: 4427-4440 [Full Text]  
  • Bruhn, J. B., Christensen, A. B., Flodgaard, L. R., Nielsen, K. F., Larsen, T. O., Givskov, M., Gram, L. (2004). Presence of Acylated Homoserine Lactones (AHLs) and AHL-Producing Bacteria in Meat and Potential Role of AHL in Spoilage of Meat. Appl. Environ. Microbiol. 70: 4293-4302 [Abstract] [Full Text]  
  • Taylor, M. W., Schupp, P. J., Baillie, H. J., Charlton, T. S., de Nys, R., Kjelleberg, S., Steinberg, P. D. (2004). Evidence for Acyl Homoserine Lactone Signal Production in Bacteria Associated with Marine Sponges. Appl. Environ. Microbiol. 70: 4387-4389 [Abstract] [Full Text]  
  • Morello, J. E., Pierson, E. A., Pierson, L. S. III (2004). Negative Cross-Communication among Wheat Rhizosphere Bacteria: Effect on Antibiotic Production by the Biological Control Bacterium Pseudomonas aureofaciens 30-84. Appl. Environ. Microbiol. 70: 3103-3109 [Abstract] [Full Text]  
  • Wang, L.-H., Weng, L.-X., Dong, Y.-H., Zhang, L.-H. (2004). Specificity and Enzyme Kinetics of the Quorum-quenching N-Acyl Homoserine Lactone Lactonase (AHL-lactonase). J. Biol. Chem. 279: 13645-13651 [Abstract] [Full Text]  
  • Scheie, A. A., Petersen, F. C. (2004). THE BIOFILM CONCEPT: CONSEQUENCES FOR FUTURE PROPHYLAXIS OF ORAL DISEASES?. CROBM 15: 4-12 [Abstract] [Full Text]  
  • Teplitski, M., Chen, H., Rajamani, S., Gao, M., Merighi, M., Sayre, R. T., Robinson, J. B., Rolfe, B. G., Bauer, W. D. (2004). Chlamydomonas reinhardtii Secretes Compounds That Mimic Bacterial Signals and Interfere with Quorum Sensing Regulation in Bacteria. Plant Physiol. 134: 137-146 [Abstract] [Full Text]  
  • Gonzalez, J. E., Marketon, M. M. (2003). Quorum Sensing in Nitrogen-Fixing Rhizobia. Microbiol. Mol. Biol. Rev. 67: 574-592 [Abstract] [Full Text]  
  • Peters, L., Konig, G. M., Wright, A. D., Pukall, R., Stackebrandt, E., Eberl, L., Riedel, K. (2003). Secondary Metabolites of Flustra foliacea and Their Influence on Bacteria. Appl. Environ. Microbiol. 69: 3469-3475 [Abstract] [Full Text]  
  • Christensen, A. B., Riedel, K., Eberl, L., Flodgaard, L. R., Molin, S., Gram, L., Givskov, M. (2003). Quorum-sensing-directed protein expression in Serratia proteamaculans B5a. Microbiology 149: 471-483 [Abstract] [Full Text]  
  • Gram, L., Grossart, H.-P., Schlingloff, A., Kiorboe, T. (2002). Possible Quorum Sensing in Marine Snow Bacteria: Production of Acylated Homoserine Lactones by Roseobacter Strains Isolated from Marine Snow. Appl. Environ. Microbiol. 68: 4111-4116 [Abstract] [Full Text]  
  • Schembri, M. A., Givskov, M., Klemm, P. (2002). An Attractive Surface: Gram-Negative Bacterial Biofilms. Sci Signal 2002: re6-re6 [Abstract] [Full Text]  
  • Reimmann, C., Ginet, N., Michel, L., Keel, C., Michaux, P., Krishnapillai, V., Zala, M., Heurlier, K., Triandafillu, K., Harms, H., Defago, G., Haas, D. (2002). Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1. Microbiology 148: 923-932 [Abstract] [Full Text]  
  • Manefield, M., Rasmussen, T. B., Henzter, M., Andersen, J. B., Steinberg, P., Kjelleberg, S., Givskov, M. (2002). Halogenated furanones inhibit quorum sensing through accelerated LuxR turnover. Microbiology 148: 1119-1127 [Abstract] [Full Text]  
  • FRAY, R. G. (2002). Altering Plant-Microbe Interaction Through Artificially Manipulating Bacterial Quorum Sensing. ANN BOT (LOND) 89: 245-253 [Abstract] [Full Text]  
  • Hentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, J. B., Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Hoiby, N., Kjelleberg, S., Givskov, M. (2002). Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology 148: 87-102 [Abstract] [Full Text]  
  • Calfee, M. W., Coleman, J. P., Pesci, E. C. (2001). Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 98: 11633-11637 [Abstract] [Full Text]  
  • Borchardt, S. A., Allain, E. J., Michels, J. J., Stearns, G. W., Kelly, R. F., McCoy, W. F. (2001). Reaction of Acylated Homoserine Lactone Bacterial Signaling Molecules with Oxidized Halogen Antimicrobials. Appl. Environ. Microbiol. 67: 3174-3179 [Abstract] [Full Text]  
  • Schauder, S., Bassler, B. L. (2001). The languages of bacteria. Genes Dev. 15: 1468-1480 [Full Text]  
  • De Kievit, T. R., Gillis, R., Marx, S., Brown, C., Iglewski, B. H. (2001). Quorum-Sensing Genes in Pseudomonas aeruginosa Biofilms: Their Role and Expression Patterns. Appl. Environ. Microbiol. 67: 1865-1873 [Abstract] [Full Text]  
  • Bollinger, N., Hassett, D. J., Iglewski, B. H., Costerton, J. W., McDermott, T. R. (2001). Gene Expression in Pseudomonas aeruginosa: Evidence of Iron Override Effects on Quorum Sensing and Biofilm-Specific Gene Regulation. J. Bacteriol. 183: 1990-1996 [Abstract] [Full Text]  
  • Andersen, J. B., Heydorn, A., Hentzer, M., Eberl, L., Geisenberger, O., Christensen, B. B., Molin, S., Givskov, M. (2001). gfp-Based N-Acyl Homoserine-Lactone Sensor Systems for Detection of Bacterial Communication. Appl. Environ. Microbiol. 67: 575-585 [Abstract] [Full Text]  
  • McDougald, D., Rice, S. A., Kjelleberg, S. (2001). SmcR-Dependent Regulation of Adaptive Phenotypes in Vibrio vulnificus. J. Bacteriol. 183: 758-762 [Abstract] [Full Text]  
  • Rasmussen, T. B., Manefield, M., Andersen, J. B., Eberl, L., Anthoni, U., Christophersen, C., Steinberg, P., Kjelleberg, S., Givskov, M. (2000). How Delisea pulchra furanones affect quorum sensing and swarming motility in Serratia liquefaciens MG1. Microbiology 146: 3237-3244 [Abstract] [Full Text]  
  • Wu, H., Song, Z., Hentzer, M., Andersen, J. B., Heydorn, A., Mathee, K., Moser, C., Eberl, L., Molin, S., Høiby, N., Givskov, M. (2000). Detection of N-acylhomoserine lactones in lung tissues of mice infected with Pseudomonas aeruginosa. Microbiology 146: 2481-2493 [Abstract] [Full Text]  
  • de Kievit, T. R., Iglewski, B. H. (2000). Bacterial Quorum Sensing in Pathogenic Relationships. Infect. Immun. 68: 4839-4849 [Full Text]  
  • Manefield, M., Harris, L., Rice, S. A., de Nys, R., Kjelleberg, S. (2000). Inhibition of Luminescence and Virulence in the Black Tiger Prawn (Penaeus monodon) Pathogen Vibrio harveyi by Intercellular Signal Antagonists. Appl. Environ. Microbiol. 66: 2079-2084 [Abstract] [Full Text]  
  • Gram, L., Christensen, A. B., Ravn, L., Molin, S., Givskov, M. (1999). Production of Acylated Homoserine Lactones by Psychrotrophic Members of the Enterobacteriaceae Isolated from Foods. Appl. Environ. Microbiol. 65: 3458-3463 [Abstract] [Full Text]  
  • Rodelas, B., Lithgow, J. K., Wisniewski-Dye, F., Hardman, A., Wilkinson, A., Economou, A., Williams, P., Downie, J. A. (1999). Analysis of Quorum-Sensing-Dependent Control of Rhizosphere-Expressed (rhi) Genes in Rhizobium leguminosarum bv. viciae. J. Bacteriol. 181: 3816-3823 [Abstract] [Full Text]  
  • Eberl, L., Molin, S., Givskov, M. (1999). Surface Motility of Serratia liquefaciens MG1. J. Bacteriol. 181: 1703-1712 [Full Text]  
  • Zhu, J., Beaber, J. W., Moré, M. I., Fuqua, C., Eberhard, A., Winans, S. C. (1998). Analogs of the Autoinducer 3-Oxooctanoyl-Homoserine Lactone Strongly Inhibit Activity of the TraR Protein of Agrobacterium tumefaciens. J. Bacteriol. 180: 5398-5405 [Abstract] [Full Text]  
  • Stickler, D. J., Morris, N. S., McLean, R. J. C., Fuqua, C. (1998). Biofilms on Indwelling Urethral Catheters Produce Quorum-Sensing Signal Molecules In Situ and In Vitro. Appl. Environ. Microbiol. 64: 3486-3490 [Abstract] [Full Text]  
  • Givskov, M., Östling, J., Eberl, L., Lindum, P. W., Christensen, A. B., Christiansen, G., Molin, S., Kjelleberg, S. (1998). Two Separate Regulatory Systems Participate in Control of Swarming Motility of Serratia liquefaciens MG1. J. Bacteriol. 180: 742-745 [Abstract] [Full Text]  
  • Srinivasan, S., Östling, J., Charlton, T., Nys, R. d., Takayama, K., Kjelleberg, S. (1998). Extracellular Signal Molecule(s) Involved in the Carbon Starvation Response of Marine Vibrio sp. Strain S14. J. Bacteriol. 180: 201-209 [Abstract] [Full Text]