Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

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J. Bacteriol., 11 1996, 6618-6622, Vol 178, No. 22
Copyright © 1996, American Society for Microbiology

Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling

M Givskov, R de Nys, M Manefield, L Gram, R Maximilien, L Eberl, S Molin, PD Steinberg and S Kjelleberg
Department of Microbiology, The Technical University of Denmark, Lyngby.

Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface- associated bacteria may be mediated by interference with bacterial regulatory systems.

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