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J. Bacteriol., May 1996, 2709-2711, Vol 178, No. 9
Copyright © 1996, American Society for Microbiology

Elevated mutation rate in mutT bacteria during starvation: evidence for DNA turnover?

BA Bridges
MRC Cell Mutation Unit, University of Sussex, Brighton, Great Britain.

The rate of appearance of prototrophic revertants when Escherichia coli tyrA14 (ochre) or trpA23 bacteria were incubated on plates lacking the required amino acid was greatly elevated when the organisms also carried a mutT mutation. One possible explanation for this result is that the amount of DNA replication or turnover under these conditions is much greater than has been previously recognized.


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Copyright © 1996 by the American Society for Microbiology. All rights reserved.