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J. Bacteriol., Jan 1997, 293-296, Vol 179, No. 1
Copyright © 1997, American Society for Microbiology

Identification, sequencing, and enzymatic activity of the erythrose-4- phosphate dehydrogenase gene of Vibrio cholerae

PA Carroll, G Zhao, SA Boyko, ME Winkler and SB Calderwood
Infectious Disease Unit, Massachusetts General Hospital, Boston 02114, USA.

We have identified a gene in Vibrio cholerae (epd) which encodes an erythrose-4-phosphate dehydrogenase activity and is located immediately downstream of an iron-regulated virulence gene, irgA, and immediately upstream of a gene encoding phosphoglycerate kinase (pgk). Expression of epd in V. cholerae is not regulated by iron, nor is it required for virulence in an infant mouse model.


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