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J Bacteriol, May 1998, p. 2756-2758, Vol. 180, No. 10
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Suppressor Scanning at Positions 177 and 236 in the Escherichia coli Lactose/H+ Cotransporter and Stereotypical Effects of Acidic Substituents That Suggest a Favored Orientation of Transmembrane Segments Relative to the Lipid Bilayer

Steven C. King* and Suzhen Li

Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77555-0641

Received 27 August 1997/Accepted 9 March 1998

Acidic substituents for Ala-177 (helix 6) or Tyr-236 (helix 7) in LacY cause effects on sugar recognition and cosubstrate coupling that are stereotypical of neutral substituents. Thus, helices 6 and 7 are probably oriented to produce little side-chain contact with the low dielectric lipid bilayer at positions 177 and 236.

* Corresponding author. Mailing address: Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX 77555-0641. Phone: (409) 772-1380. Fax: (409) 772-3381. E-mail: steven.king{at}utmb.edu.

J Bacteriol, May 1998, p. 2756-2758, Vol. 180, No. 10
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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