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J Bacteriol, May 1998, p. 2788-2791, Vol. 180, No. 10
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Functional Similarity between Archaeal and Bacterial CorA Magnesium Transporters

Ronald L. Smith,1 Erik Gottlieb,1 Lisa M. Kucharski,2 and Michael E. Maguire2,*

Department of Biology, University of Texas at Arlington, Arlington, Texas 76019,1 and Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-49652

Received 12 December 1997/Accepted 18 March 1998

The constitutively expressed CorA Mg2+ transporter is the major Mg2+ influx system of Salmonella typhimurium and Escherichia coli. Genomic sequence data indicated the presence of a homolog in the archaeal organism Methanococcus jannaschii. The putative M. jannaschii CorA was expressed in an Mg2+-transport-deficient strain of S. typhimurium to determine its functional characteristics. The archaeal CorA homolog is a functional Mg2+ uptake system when expressed in S. typhimurium and has properties which are highly similar to those of the normal CorA transporter of S. typhimurium despite having a low level of sequence identity with the protein and being expressed in a lipid membrane of quite different composition than normal. This implies that the overall function of the proteins is the same and further suggests that their structures are very similar.

* Corresponding author. Mailing address: Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106-4965. Phone: (216) 368-6186. Fax: (216) 368-3395. E-mail: mem6{at}po.cwru.edu.

J Bacteriol, May 1998, p. 2788-2791, Vol. 180, No. 10
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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