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J Bacteriol, June 1998, p. 3257-3259, Vol. 180, No. 12
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Activation of Bacteriophage Mu mom Transcription by C Protein Does Not Require Specific Interaction with the Carboxyl-Terminal Region of the alpha  or sigma 70 Subunit of Escherichia coli RNA Polymerase

Weiyong Sun,1 Stanley Hattman,1,* Noboyuki Fujita,2 and Akira Ishihama2

Department of Biology, University of Rochester, Rochester, New York 14627,1 and Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411, Japan2

Received 22 December 1997/Accepted 15 April 1998

Late in its growth cycle, transcription of the phage Mu mom promoter (Pmom) is activated by the phage gene product, C, a site-specific DNA binding protein. In vitro transcription analyses showed that this activation does not require specific contacts between C and the carboxyl-terminal region of the alpha  or sigma 70 subunit of Escherichia coli RNA polymerase. Unexpectedly, these results are in contrast to those known for another Mu-encoded transcriptional activator, Mor, which has a high degree of sequence identity with C and appears to interact with the carboxyl termini of both alpha  and sigma 70.

* Corresponding author. Mailing address: Department of Biology, University of Rochester, Rochester, NY 14627-0211. Phone: (716) 275-8046. Fax: (716) 275-2070. E-mail: modDNA{at}uhura.cc.rochester.edu.

J Bacteriol, June 1998, p. 3257-3259, Vol. 180, No. 12
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Jiang, Y., Howe, M. M. (2008). Regional mutagenesis of the gene encoding the phage Mu late gene activator C identifies two separate regions important for DNA binding. Nucleic Acids Res 36: 6396-6405 [Abstract] [Full Text]  
  • Basak, S., Nagaraja, V. (2001). DNA Unwinding Mechanism for the Transcriptional Activation of momP1 Promoter by the Transactivator Protein C of Bacteriophage Mu. J. Biol. Chem. 276: 46941-46945 [Abstract] [Full Text]  


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