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Vol. 180, Issue 13, 3486-3490, July 1, 1998

NOTE
Aberrant Cell Division and Random FtsZ Ring Positioning in Escherichia coli cpxA* Mutants

Joe Pogliano1, Jian Ming Dong1, Peter De Wulf1, Dierdre Furlong1, Dana Boyd1, Richard Losick2, Kit Pogliano2, and E. C. C. Lin1

1 Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115,1 and 2 Department of Molecular and Cellular Biology, The Biological Laboratories, Harvard University, Cambridge, Massachusetts 021382

In Escherichia coli, certain mutations in the cpxA gene (encoding a sensor kinase of a two-component signal transduction system) randomize the location of FtsZ ring assembly and dramatically affect cell division. However, deletion of the cpxRA operon, encoding the sensor kinase and its cognate regulator CpxR, has no effect on division site biogenesis. It appears that certain mutant sensor kinases (CpxA*) either exhibit hyperactivity on CpxR or extend their signalling activity to one or more noncognate response regulators involved in cell division.

Copyright © 1998 by American Society for Microbiology


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