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Journal of Bacteriology, August 1998, p. 4007-4010, Vol. 180, No. 15
Laboratory for Molecular Biology, University
of Illinois at Chicago, Chicago, Illinois 60607
Received 19 March 1998/Accepted 19 May 1998
tagA, tagD, and tuaA operons
are responsible for the synthesis of cell wall anionic polymer,
teichoic acid, and teichuronic acid, respectively, in Bacillus
subtilis. Under phosphate starvation conditions, teichuronic acid
is synthesized while teichoic acid synthesis is inhibited. Expression
of these genes is controlled by PhoP-PhoR, a two-component system. It
has been proposed that PhoP~P plays a key role in the activation of
tuaA and the repression of tagA and
tagD. In this study, we demonstrated the role of PhoP~P in the switch process from teichoic acid synthesis to teichuronic acid
synthesis, by using an in vitro transcription system. The results
indicate that PhoP~P is sufficient to repress the transcription of
the tagA and tagD promoters and also to
activate the transcription of the tuaA promoter.
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Role of PhoP~P in Transcriptional Regulation of Genes Involved
in Cell Wall Anionic Polymer Biosynthesis in Bacillus
subtilis
*
Corresponding author. Mailing address: University of
Illinois at Chicago, Laboratory for Molecular Biology (M/C567), 900 S. Ashland Ave., Chicago, IL 60607. Phone: (312) 996-5469. Fax: (312) 413-2691. E-mail: Hulett{at}uic.edu.
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