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Journal of Bacteriology, August 1998, p. 4007-4010, Vol. 180, No. 15
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Role of PhoP~P in Transcriptional Regulation of Genes Involved in Cell Wall Anionic Polymer Biosynthesis in Bacillus subtilis

Ying Qi and F. Marion Hulett*

Laboratory for Molecular Biology, University of Illinois at Chicago, Chicago, Illinois 60607

Received 19 March 1998/Accepted 19 May 1998

tagA, tagD, and tuaA operons are responsible for the synthesis of cell wall anionic polymer, teichoic acid, and teichuronic acid, respectively, in Bacillus subtilis. Under phosphate starvation conditions, teichuronic acid is synthesized while teichoic acid synthesis is inhibited. Expression of these genes is controlled by PhoP-PhoR, a two-component system. It has been proposed that PhoP~P plays a key role in the activation of tuaA and the repression of tagA and tagD. In this study, we demonstrated the role of PhoP~P in the switch process from teichoic acid synthesis to teichuronic acid synthesis, by using an in vitro transcription system. The results indicate that PhoP~P is sufficient to repress the transcription of the tagA and tagD promoters and also to activate the transcription of the tuaA promoter.

* Corresponding author. Mailing address: University of Illinois at Chicago, Laboratory for Molecular Biology (M/C567), 900 S. Ashland Ave., Chicago, IL 60607. Phone: (312) 996-5469. Fax: (312) 413-2691. E-mail: Hulett{at}uic.edu.

Journal of Bacteriology, August 1998, p. 4007-4010, Vol. 180, No. 15
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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