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Journal of Bacteriology, August 1998, p. 4212-4218, Vol. 180, No. 16
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

One of Two OsmC Homologs in Bacillus subtilis Is Part of the sigma B-Dependent General Stress Regulon

Uwe Völker,1,* Kasper Krogh Andersen,2 Haike Antelmann,1 Kevin M. Devine,2 and Michael Hecker1

Institut für Mikrobiologie und Molekularbiologie, Ernst-Moritz-Arndt-Universität Greifswald, 17487 Greifswald, Germany,1 and Department of Genetics, Trinity College, Dublin 2, Ireland2

Received 9 February 1998/Accepted 15 June 1998

In this report we present the identification and analysis of two Bacillus subtilis genes, yklA and ykzA, which are homologous to the partially RpoS-controlled osmC gene from Escherichia coli. The yklA gene is expressed at higher levels in minimal medium than in rich medium and is driven by a putative vegetative promoter. Expression of ykzA is not medium dependent but increases dramatically when cells are exposed to stress and starvation. This stress-induced increase in ykzA expression is absolutely dependent on the alternative sigma factor sigma B, which controls a large stationary-phase and stress regulon. ykzA is therefore another example of a gene common to the RpoS and sigma B stress regulons of E. coli and B. subtilis, respectively. The composite complex expression pattern of the two B. subtilis genes is very similar to the expression profile of osmC in E. coli.

* Corresponding author. Present address: Laboratorium für Mikrobiologie, Philipps-Universität-Marburg, Karl-von-Frisch-Str., 35043 Marburg, Germany. Phone: 0049-6421-283478. Fax: 0049-6421-288979. E-mail: voelker{at}su1701.biologie.uni-marburg.de.

Journal of Bacteriology, August 1998, p. 4212-4218, Vol. 180, No. 16
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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