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Journal of Bacteriology, August 1998, p. 4287-4290, Vol. 180, No. 16
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Escherichia coli Starvation Gene cstC Is Involved in Amino Acid Catabolism

C. D. Fraley,dagger J. H. Kim,Dagger M. P. McCann,§ and A. Matin*

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305

Received 14 January 1998/Accepted 3 June 1998

Escherichia coli strains mutant in the starvation gene cstC grow normally in a mineral salts medium but are impaired in utilizing amino acids as nitrogen sources. They are also compromised in starvation survival, where amino acid catabolism is important. The cstC gene encodes a 406-amino-acid protein that closely resembles the E. coli ArgD protein, which is involved in arginine biosynthesis. We postulate that CstC is a counterpart of ArgD in an amino acid catabolic pathway. The cstC upstream region contains several regulatory consensus sequences. Both sigma S and sigma 54 promoters are probably involved in cstC transcription and appear to compete with each other, presumably to match cstC expression to the cellular amino acid catabolic needs.

* Corresponding author. Mailing address: D317 Sherman Fairchild Science Building, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305-5402. Phone: (650) 725-4745. Fax: (650) 725-6757. E-mail: a.matin{at}forsythe.stanford.edu.

dagger Present address: Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305-5307.

Dagger Present address: Department of Food Science & Technology, College of Agriculture, Gyeongsang National University, Chinju, Korea 660-701.

§ Department of Biology, St. Joseph's University, Philadelphia, PA 19131.

Journal of Bacteriology, August 1998, p. 4287-4290, Vol. 180, No. 16
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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