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Journal of Bacteriology, September 1998, p. 4942-4945, Vol. 180, No. 18
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Na+-Responsive ntp Operon Is Indispensable for Homeostatis of K+ and Na+ in Enterococcus hirae at Limited Proton Potential

Miyuki Kawano, Kazuei Igarashi, and Yoshimi Kakinuma*

Faculty of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba 263-8522, Japan

Received 9 April 1998/Accepted 13 July 1998

Enterococcus hirae ATCC 9790 grew well in Na+-deficient, low-K+ medium, but growth was inhibited by carbonylcyanide m-chlorophenylhydrazone (CCCP). Growth inhibition and decrease of cellular K+ levels in the presence of CCCP were relieved by the addition of Na+ and a high concentration of K+. In contrast, in the mutant defective in Na+-ATPase or the NtpJ component of the KtrII K+ uptake system, CCCP-induced growth inhibition was rescued by a high concentration of K+ but not of Na+. These transporters are thus indispensable for homeostatis of K+ and Na+ at low proton potential.

* Corresponding author. Mailing address: Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. Phone: 81-43-290-2898. Fax: 81-43-290-2900. E-mail: yoshimi{at}athenaeum.p.chiba-u.ac.jp.

Journal of Bacteriology, September 1998, p. 4942-4945, Vol. 180, No. 18
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Kawano, M., Abuki, R., Igarashi, K., Kakinuma, Y. (2000). Evidence for Na+ Influx via the NtpJ Protein of the KtrII K+ Uptake System in Enterococcus hirae. J. Bacteriol. 182: 2507-2512 [Abstract] [Full Text]  
  • Kosono, S., Ohashi, Y., Kawamura, F., Kitada, M., Kudo, T. (2000). Function of a Principal Na+/H+ Antiporter, ShaA, Is Required for Initiation of Sporulation in Bacillus subtilis. J. Bacteriol. 182: 898-904 [Abstract] [Full Text]  


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