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Journal of Bacteriology, October 1998, p. 5235-5239, Vol. 180, No. 19
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Genetic Analysis of Mecillinam-Resistant Mutants of Caulobacter crescentus Deficient in Stalk Biosynthesis

Lisa C. Seitz and Yves V. Brun*

Department of Biology, Indiana University, Bloomington, Indiana 47405

Received 22 April 1998/Accepted 24 July 1998

Stalk synthesis in Caulobacter crescentus is a developmentally controlled and spatially restricted event that requires the synthesis of peptidoglycan at the stalk-cell body junction. We show that the beta -lactam antibiotic mecillinam prevents stalk synthesis by inhibiting stalk elongation. In addition, mecillinam causes an increase in the diameter of the stalk at the stalk-cell body junction. We describe two mutations that confer resistance to mecillinam and that prevent stalk elongation. These mutations are probably allelic, and they map to a locus previously not associated with stalk synthesis.

* Corresponding author. Mailing address: Department of Biology, Indiana University, Bloomington, IN 47405. Phone: (812) 855-8860. Fax: (812) 855-6705. E-mail: ybrun{at}bio.indiana.edu.

Journal of Bacteriology, October 1998, p. 5235-5239, Vol. 180, No. 19
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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