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Journal of Bacteriology, November 1998, p. 5776-5779, Vol. 180, No. 21
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The SecA Subunit of Escherichia coli Preprotein Translocase Is Exposed to the Periplasm

Jerry Eichlerdagger and William Wickner*

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755-3844

Received 12 June 1998/Accepted 18 August 1998

SecA undergoes conformational changes during translocation, inserting domains into and across the membrane or enhancing the protease resistance of these domains. We now show that some SecA bound at SecYEG is accessible from the periplasm to a membrane-impermeant probe in cells with a permeabilized outer membrane but an intact plasma membrane.

* Corresponding author. Mailing address: Department of Biochemistry, Dartmouth Medical School, 7200 Vail Building, Hanover, NH 03755-3844. Phone: (603) 650-1701. Fax: (603) 650-1353. E-mail: William.T.Wickner{at}Dartmouth.edu.

dagger Present address: Department of Life Sciences, Ben Gurion University of the Negev, Beersheva 84105, Israel.

Journal of Bacteriology, November 1998, p. 5776-5779, Vol. 180, No. 21
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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