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Journal of Bacteriology, November 1998, p. 6043-6047, Vol. 180, No. 22
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Transport of Intact Porphyrin by HpuAB, the Hemoglobin-Haptoglobin Utilization System of Neisseria meningitidis

L. A. Lewis,* M.-H. Sung, M. Gipson, K. Hartman, and D. W. Dyer

Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73103

Received 26 May 1998/Accepted 9 September 1998

The meningococcal hemA gene was cloned and used to construct a porphyrin biosynthesis mutant. An analysis of the hemA mutant indicated that meningococci can transport intact porphyrin from heme (Hm), hemoglobin (Hb), and Hb-haptoglobin (Hp). By constructing a HemA- HpuAB- double mutant, we demonstrated that HpuAB is required for the transport of porphyrin from Hb and Hb-Hp.

* Corresponding author. Mailing address: 1053 BMSB, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104. Phone: (405) 271-1201. Fax: (405) 271-3117. E-mail: llewis{at}rex.uokhsc.edu.

Journal of Bacteriology, November 1998, p. 6043-6047, Vol. 180, No. 22
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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