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Journal of Bacteriology, November 1998, p. 6068-6071, Vol. 180, No. 22
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

mmr, a Mycobacterium tuberculosis Gene Conferring Resistance to Small Cationic Dyes and Inhibitors

Edda De Rossi, Manuela Branzoni, Rita Cantoni, Anna Milano, Giovanna Riccardi, and Orio Ciferri*

Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy

Received 20 April 1998/Accepted 4 September 1998

The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.

* Corresponding author. Mailing address: Department of Genetics and Microbiology, via Abbiategrasso 207, 27100 Pavia, Italy. Phone: (39-382) 505576. Fax: (39-382) 528496. E-mail: ociferri{at}pillo.unipv.it.

Journal of Bacteriology, November 1998, p. 6068-6071, Vol. 180, No. 22
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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