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Journal of Bacteriology, December 1998, p. 6424-6428, Vol. 180, No. 23
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Role of the C Terminus of FtsK in Escherichia coli Chromosome Segregation

Xuan-Chuan Yu, Elizabeth K. Weihe, and William Margolin*

Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, Texas 77030

Received 28 July 1998/Accepted 14 September 1998

FtsK is essential for Escherichia coli cell division. We report that cells lacking the C terminus of FtsK are defective in chromosome segregation as well as septation, often exhibiting asymmetrically positioned nucleoids and large anucleate regions. Combining the corresponding truncated ftsK gene with a mukB null mutation resulted in a synthetic lethal phenotype. When the truncated ftsK was combined with a minCDE deletion, chains of minicells were generated, many of which contained DNA. These results suggest that the C terminus of FtsK has an important role in chromosome partitioning.

* Corresponding author. Mailing address: Department of Microbiology and Molecular Genetics, University of Texas Medical School, Houston, TX 77030. Phone: (713) 500-5452. Fax: (713) 500-5499. E-mail: margolin{at}utmmg.med.uth.tmc.edu.

Journal of Bacteriology, December 1998, p. 6424-6428, Vol. 180, No. 23
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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