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J Bacteriol, April 1998, p. 1944-1946, Vol. 180, No. 7
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Levels of the Vsr Endonuclease Do Not Regulate Stationary-Phase Reversion of a Lac Frameshift Allele in Escherichia coli

Patricia L. Foster^* and William A. Rosche

Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118-2394

Received 30 October 1997/Accepted 29 January 1998

Vsr endonuclease, which initiates very short patch repair, has been hypothesized to regulate mutation in stationary-phase cells. Overexpression of Vsr does dramatically increase the stationary-phase reversion of a Lac frameshift allele, but the absence of Vsr has no effect. Thus, at least in this case, Vsr has no regulatory role in stationary-phase mutation, and the effects of Vsr overproduction are likely to be artifactual.

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^* Corresponding author. Mailing address: S107, Boston University School of Public Health, Boston University School of Medicine, 715 Albany St., Boston, MA 02118-2394. Phone: (617) 638-5617. Fax: (617) 638-5677. E-mail: pfoster{at}bu.edu.

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