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J Bacteriol, April 1998, p. 1970-1972, Vol. 180, No. 7
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Growth Rate-Dependent Accumulation of RNA from Plasmid-Borne rRNA Operons in Escherichia coli

Bradley S. Stevenson and Thomas M. Schmidt*

Department of Microbiology and Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824

Received 21 July 1997/Accepted 26 January 1998

Inadequate regulation of the expression of additional plasmid-borne rRNA operons in Escherichia coli was exaggerated at slow growth rates, resulting in increases of approximately 100% for RNA concentration and 33% for doubling time. These observations are consistent with the hypothesis that multiple rRNA operons constitute a metabolic burden at slow growth rates.

* Corresponding author. Mailing address: Department of Microbiology, Giltner Hall, Michigan State University, E. Lansing, MI 48824-1101. Phone: (517) 353-1796. Fax: (517) 353-8957. E-mail: tschmidt{at}pilot.msu.edu.




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