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J Bacteriol, April 1998, p. 2265-2270, Vol. 180, No. 8
0021-9193/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

The Bacillus subtilis galE Gene Is Essential in the Presence of Glucose and Galactose

Oliver Krispin and Rudolf Allmansberger*

Lehrstuhl für Mikrobiologie, Universität Erlangen-Nürnberg, D-91058 Erlangen, Germany

Received 26 November 1997/Accepted 19 February 1998

Bacillus subtilis is unable to grow by consuming galactose because it is unable to transport it into the cell. The transcription of galE is not influenced by galactose but is repressed by glucose. Galactose is toxic for galE-negative bacteria because it results in elevated levels of metabolic intermediates. These negative effects are reduced in galK and galT mutants. Glucose is also toxic for galE-negative strains.

* Corresponding author. Mailing address: Lehrstuhl für Mikrobiologie, Universität Erlangen-Nürnberg, Staudtstr. 5, D-91058 Erlangen, Germany. Phone: 49 9131 858084. Fax: 49 9131 858082. E-mail: rallmans{at}biologie.uni-erlangen.de.




This article has been cited by other articles:

  • Schaffer, C., Wugeditsch, T., Messner, P., Whitfield, C. (2002). Functional Expression of Enterobacterial O-Polysaccharide Biosynthesis Enzymes in Bacillus subtilis. Appl. Environ. Microbiol. 68: 4722-4730 [Abstract] [Full Text]  
  • Fridjonsson, O., Mattes, R. (2001). Production of Recombinant {alpha}-Galactosidases in Thermus thermophilus. Appl. Environ. Microbiol. 67: 4192-4198 [Abstract] [Full Text]  
  • Krispin, O., Allmansberger, R. (1998). . J. Bacteriol. 180: 3250-3252 [Abstract]  


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