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Journal of Bacteriology, May 1999, p. 3298-3302, Vol. 181, No. 10
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
A Novel Campylobacter jejuni
Two-Component Regulatory System Important for Temperature-Dependent
Growth and Colonization
Ana M.
Brás,1
Shimonti
Chatterjee,1
Brendan W.
Wren,2
Diane G.
Newell,3 and
Julian M.
Ketley1,*
Department of Genetics, University of
Leicester, Leicester,1 Department of
Medical Microbiology, St. Bartholomew's and the Royal London
School of Medicine and Dentistry, London,2
and Applied and Molecular Immunology Unit, Central
Veterinary Laboratory, New Haw, Addlestone,
Surrey,3 United Kingdom
Received 9 November 1998/Accepted 3 March 1999
Campylobacter jejuni colonizes the intestines of
domestic and wild animals and is a common cause of human diarrheal
disease. We identified a two-component regulatory system, designated
the RacR-RacS (reduced ability to colonize) system, that is involved in
a temperature-dependent signalling pathway. A mutation of the response
regulator gene racR reduced the organism's ability to colonize the chicken intestinal tract and resulted in
temperature-dependent changes in its protein profile and growth characteristics.
*
Corresponding author. Mailing address: Department of
Genetics, University of Leicester, University Rd., Leicester LE1 7RH, United Kingdom. Phone: 44-116-2523434. Fax: 44-116-2523378. E-mail: ket{at}le.ac.uk.
Journal of Bacteriology, May 1999, p. 3298-3302, Vol. 181, No. 10
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.
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