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Journal of Bacteriology, May 1999, p. 3298-3302, Vol. 181, No. 10
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

A Novel Campylobacter jejuni Two-Component Regulatory System Important for Temperature-Dependent Growth and Colonization

Ana M. Brás,1 Shimonti Chatterjee,1 Brendan W. Wren,2 Diane G. Newell,3 and Julian M. Ketley1,*

Department of Genetics, University of Leicester, Leicester,1 Department of Medical Microbiology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London,2 and Applied and Molecular Immunology Unit, Central Veterinary Laboratory, New Haw, Addlestone, Surrey,3 United Kingdom

Received 9 November 1998/Accepted 3 March 1999

Campylobacter jejuni colonizes the intestines of domestic and wild animals and is a common cause of human diarrheal disease. We identified a two-component regulatory system, designated the RacR-RacS (reduced ability to colonize) system, that is involved in a temperature-dependent signalling pathway. A mutation of the response regulator gene racR reduced the organism's ability to colonize the chicken intestinal tract and resulted in temperature-dependent changes in its protein profile and growth characteristics.

* Corresponding author. Mailing address: Department of Genetics, University of Leicester, University Rd., Leicester LE1 7RH, United Kingdom. Phone: 44-116-2523434. Fax: 44-116-2523378. E-mail: ket{at}le.ac.uk.

Journal of Bacteriology, May 1999, p. 3298-3302, Vol. 181, No. 10
0021-9193/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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